Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC049
Test administered by neuromedic@manusdevices.net
Test date and time 2022-09-01 08:02
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 3x1/4 New patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 19 individuals with a value less than 0.57 were subsequently diagnosed with PD. That is, 45.24% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.57 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 34, 'TN': 25, 'TP': 8, 'FP': 5}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 9, 'TN': 9, 'TP': 33, 'FP': 21}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 39, 'TN': 29, 'TP': 3, 'FP': 1}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 9, 'TN': 7, 'TP': 33, 'FP': 23}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 10.032
timePerCircleCoV 0.335633
timePerCircleSlope -0.0962254
meanError 1.93475
tremorFreq 6.54297
tremorRelPower 25.6735
tremorGyroAmpMean 0.0119896
tremorGyroAmpSlope 0.00566406
tremorGyroAmpCoV 0.455825
tremorCoordAmpMean 0.029644
tremorCoordAmpSlope 0.00454257
tremorCoordAmpCoV 0.308208
tremorAccAmpMean 0.0194181
tremorAccAmpSlope 0.00370694
tremorAccAmpCoV 0.346979
tremorPcRelVar 0.700956
tremorPcX -0.469192
tremorPcY 0.883096

Circle Segment 1

Duration 16.6 s, Accuracy Estimate 4.333 (lower is better)

Circle Segment 2

Duration 14.88 s, Accuracy Estimate 1.549 (lower is better)

Circle Segment 3

Duration 10.96 s, Accuracy Estimate 1.628 (lower is better)

Circle Segment 4

Duration 7.88 s, Accuracy Estimate 1.711 (lower is better)

Circle Segment 5

Duration 9.68 s, Accuracy Estimate 1.514 (lower is better)

Circle Segment 6

Duration 9.44 s, Accuracy Estimate 1.099 (lower is better)

Circle Segment 7

Duration 9.2 s, Accuracy Estimate 1.767 (lower is better)

Circle Segment 8

Duration 8.8 s, Accuracy Estimate 1.361 (lower is better)

Circle Segment 9

Duration 7.28 s, Accuracy Estimate 2.037 (lower is better)

Circle Segment 10

Duration 5.6 s, Accuracy Estimate 2.348 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 20.432
timePerSpiralCoV 0.156856
timePerSpiralSlope -0.0421917
meanError 2.84437
tremorFreq 5.56641
tremorRelPower 39.2417
tremorGyroAmpMean 0.0288339
tremorGyroAmpSlope 0.00307972
tremorGyroAmpCoV 0.458412
tremorCoordAmpMean 0.0525409
tremorCoordAmpSlope 0.0011459
tremorCoordAmpCoV 0.355403
tremorAccAmpMean 0.0558381
tremorAccAmpSlope 0.000892662
tremorAccAmpCoV 0.213336
tremorPcRelVar 0.760738
tremorPcX 0.713872
tremorPcY 0.700276

Spiral Segment 1

Duration 21.84 s, Accuracy Estimate 2.379 (lower is better)

Spiral Segment 2

Duration 25.96 s, Accuracy Estimate 2.487 (lower is better)

Spiral Segment 3

Duration 20.44 s, Accuracy Estimate 2.619 (lower is better)

Spiral Segment 4

Duration 23.96 s, Accuracy Estimate 2.425 (lower is better)

Spiral Segment 5

Duration 20.4 s, Accuracy Estimate 2.7 (lower is better)

Spiral Segment 6

Duration 21.92 s, Accuracy Estimate 3.008 (lower is better)

Spiral Segment 7

Duration 18.4 s, Accuracy Estimate 2.887 (lower is better)

Spiral Segment 8

Duration 19.48 s, Accuracy Estimate 3.358 (lower is better)

Spiral Segment 9

Duration 15.64 s, Accuracy Estimate 3.411 (lower is better)

Spiral Segment 10

Duration 16.28 s, Accuracy Estimate 3.17 (lower is better)

Elel

eDurationMean 0.780128
eDurationStd 0.470654
eDurationStdnorm 0.603303
eDurationMedian 0.61
eDurationQuartdelta 0.36
eDurationQuartdeltanorm 0.590164
eDurationKurt 8.64871
eDurationTrenddiff -0.325
eDurationTrendratio 0.606061
eWidthMean 4.392
eWidthStd 1.91214
eWidthStdnorm 0.43537
eWidthMedian 4.095
eWidthQuartdelta 2.42775
eWidthQuartdeltanorm 0.592857
eWidthKurt 6.24492
eWidthTrenddiff -1.521
eWidthTrendratio 0.657895
eHeightMean 9.255
eHeightStd 2.72225
eHeightStdnorm 0.294138
eHeightMedian 9.36
eHeightQuartdelta 3.3345
eHeightQuartdeltanorm 0.35625
eHeightKurt 4.72956
eHeightTrenddiff -0.702
eHeightTrendratio 0.926829
eAspectMean 0.467235
eAspectStd 0.120291
eAspectStdnorm 0.257453
eAspectMedian 0.463415
eAspectQuartdelta 0.125225
eAspectQuartdeltanorm 0.270223
eAspectKurt 3.30356
eAspectTrenddiff -0.116129
eAspectTrendratio 0.775
eSlantMean -0.269722
eSlantStd 0.116601
eSlantStdnorm -0.432301
eSlantMedian -0.270833
eSlantQuartdelta 0.158696
eSlantQuartdeltanorm -0.585954
eSlantKurt 2.79187
eSlantTrenddiff -0.0166297
eRtopMean 0.569064
eRtopStd 0.0901008
eRtopStdnorm 0.158332
eRtopMedian 0.578947
eRtopQuartdelta 0.141007
eRtopQuartdeltanorm 0.243557
eRtopKurt 2.19003
eRtopTrenddiff -0.0876068
eRbotMean 1.20215
eRbotStd 0.385935
eRbotStdnorm 0.321038
eRbotMedian 1.14286
eRbotQuartdelta 0.452906
eRbotQuartdeltanorm 0.396293
eRbotKurt 4.44431
eRbotTrenddiff 0.25
eRrightMean 0.753038
eRrightStd 0.091844
eRrightStdnorm 0.121965
eRrightMedian 0.761194
eRrightQuartdelta 0.0892838
eRrightQuartdeltanorm 0.117294
eRrightKurt 3.44095
eRrightTrenddiff 0.0308527
eRleftMean 0.56338
eRleftStd 0.090263
eRleftStdnorm 0.160217
eRleftMedian 0.576087
eRleftQuartdelta 0.111638
eRleftQuartdeltanorm 0.193787
eRleftKurt 2.89438
eRleftTrenddiff 0.0171055
lDurationMean 1.505
lDurationStd 0.636857
lDurationStdnorm 0.423161
lDurationMedian 1.45
lDurationQuartdelta 0.72875
lDurationQuartdeltanorm 0.502586
lDurationKurt 4.47902
lDurationTrenddiff -0.6775
lDurationTrendratio 0.604956
lWidthMean 8.6996
lWidthStd 3.43656
lWidthStdnorm 0.395025
lWidthMedian 7.956
lWidthQuartdelta 2.8665
lWidthQuartdeltanorm 0.360294
lWidthKurt 11.9358
lWidthTrenddiff -1.3455
lWidthTrendratio 0.842466
lHeightMean 30.9244
lHeightStd 6.97509
lHeightStdnorm 0.225553
lHeightMedian 30.069
lHeightQuartdelta 6.87375
lHeightQuartdeltanorm 0.228599
lHeightKurt 3.48182
lHeightTrenddiff -7.1955
lHeightTrendratio 0.779964
lAspectMean 0.287122
lAspectStd 0.1123
lAspectStdnorm 0.391121
lAspectMedian 0.263959
lAspectQuartdelta 0.0852903
lAspectQuartdeltanorm 0.323119
lAspectKurt 13.0549
lAspectTrenddiff 0.00562749
lAspectTrendratio 1.02164
lSlantMean -0.177934
lSlantStd 0.101987
lSlantStdnorm -0.573177
lSlantMedian -0.186813
lSlantQuartdelta 0.12743
lSlantQuartdeltanorm -0.682127
lSlantKurt 3.10602
lSlantTrenddiff -0.041043
lRtopMean 0.454845
lRtopStd 0.147566
lRtopStdnorm 0.324432
lRtopMedian 0.445545
lRtopQuartdelta 0.185383
lRtopQuartdeltanorm 0.416082
lRtopKurt 2.85782
lRtopTrenddiff -0.0513292
lRbotMean 1.12185
lRbotStd 0.30487
lRbotStdnorm 0.271757
lRbotMedian 1.15385
lRbotQuartdelta 0.342213
lRbotQuartdeltanorm 0.296585
lRbotKurt 3.0728
lRbotTrenddiff 0.0593826
lRrightMean 0.606897
lRrightStd 0.176732
lRrightStdnorm 0.291206
lRrightMedian 0.595455
lRrightQuartdelta 0.222068
lRrightQuartdeltanorm 0.372939
lRrightKurt 2.39624
lRrightTrenddiff -0.00595384
lRleftMean 0.669528
lRleftStd 0.158741
lRleftStdnorm 0.237094
lRleftMedian 0.694444
lRleftQuartdelta 0.241071
lRleftQuartdeltanorm 0.347142
lRleftKurt 2.56809
lRleftTrenddiff -0.0467524

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.768115
sumTouchScores 23.0434
meanMovementTime 0.585
numTouches 30
undershootPercentage 10
overshootPercentage 26.6667

fitts_short data not in signals file.

FITTS Long Modified

meanTouchScore 0.879665
sumTouchScores 16.7136
meanMovementTime 1.05389
numTouches 19
undershootPercentage 5.26316
overshootPercentage 15.7895

fitts_long data not in signals file.

ZigZag

numZigzags 5
timePerZigzagMean 30.488
timePerZigzagCoV 0.172247
timePerZigzagSlope -0.0490685
meanError 1.9343
tremorFreq 5.27344
tremorRelPower 26.134
tremorGyroAmpMean 0.0250325
tremorGyroAmpSlope 0.00074426
tremorGyroAmpCoV 0.372175
tremorCoordAmpMean 0.0714016
tremorCoordAmpSlope -0.000919389
tremorCoordAmpCoV 0.755546
tremorAccAmpMean 0.0465344
tremorAccAmpSlope 0.000544704
tremorAccAmpCoV 0.413766
tremorPcRelVar 0.773574
tremorPcX -0.0139987
tremorPcY 0.999902

ZigZag Segment 1

Duration 28.96 s, Accuracy Estimate 2.236 (lower is better)

ZigZag Segment 2

Duration 38.48 s, Accuracy Estimate 1.816 (lower is better)

ZigZag Segment 3

Duration 28.12 s, Accuracy Estimate 1.74 (lower is better)

ZigZag Segment 4

Duration 32.32 s, Accuracy Estimate 1.979 (lower is better)

ZigZag Segment 5

Duration 24.56 s, Accuracy Estimate 1.901 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 25.336
timePerZigzagCoV 0.13907
timePerZigzagSlope -0.0574676
zigzagHeightMean 86.061
zigzagHeightCoV 0.0584502
zigzagHeightSlope 0.021331
meanError 0.0632598
tremorFreq 5.56641
tremorRelPower 39.4135
tremorGyroAmpMean 0.0254558
tremorGyroAmpSlope 0.00169875
tremorGyroAmpCoV 0.448067
tremorCoordAmpMean 0.0819439
tremorCoordAmpSlope 0.00284901
tremorCoordAmpCoV 0.601376
tremorAccAmpMean 0.0643838
tremorAccAmpSlope 0.00150511
tremorAccAmpCoV 0.269837
tremorPcRelVar 0.743736
tremorPcX -0.240754
tremorPcY -0.970586

ZigZag Offset Segment 1

Duration 26.8 s, Accuracy Estimate 0.098 (lower is better)

ZigZag Offset Segment 2

Duration 26.04 s, Accuracy Estimate 0.059 (lower is better)

ZigZag Offset Segment 3

Duration 30.08 s, Accuracy Estimate 0.085 (lower is better)

ZigZag Offset Segment 4

Duration 22.44 s, Accuracy Estimate 0.039 (lower is better)

ZigZag Offset Segment 5

Duration 21.32 s, Accuracy Estimate 0.036 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.78}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.57}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.9895857329116751}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9008694062676317}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.5664118133096921}